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User:Mr. Ibrahem/Travoprost

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Mr. Ibrahem/Travoprost
Clinical data
Trade namesTravatan, Izba, others
AHFS/Drugs.comMonograph
MedlinePlusa602027
License data
Pregnancy
category
Routes of
administration		Topical (eye drops)
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
MetabolismActivation by ester hydrolysis, deactivation by beta oxidation, OH-oxidation, double bond reduction
Onset of action2 hours
Elimination half-life1.5 hours (in aqueous fluid)
45 minutes (terminal)
Duration of action≥ 24 hours
ExcretionMainly via kidney
Identifiers
  • Propan-2-yl 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)
    phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate
Chemical and physical data
FormulaC26H35F3O6
Molar mass500.555 g·mol−1
3D model (JSmol)
  • FC(F)(F)c2cc(OC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C\C=C/CCCC(=O)OC(C)C)ccc2
  • InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1 checkY
  • Key:MKPLKVHSHYCHOC-AHTXBMBWSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Travoprost, sold under the brand name Travatan among others, is medications used to treat high pressure inside the eye including glaucoma.[3] Specifically it is used for open angle glaucoma when other agents are not sufficient.[4][3] It is used as an eye drop.[3] Effects generally occur within 2 hours.[3]

Common side effects include red eyes, blurry vision, eye pain, dry eyes, and change in color of the eyes.[3][4] Other significant side effects may include cataracts.[4] Use during pregnancy or breastfeeding is generally not recommended.[4] It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.[3]

Travoprost was approved for medical use in the United States in 2001.[3] It is available as a generic medication in the United Kingdom.[4] A 2.5 milliliter bottle in the United Kingdom costs the NHS about 7.30 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$177.[5] In 2017, it was the 212th most commonly prescribed medication in the United States, with more than two million prescriptions.[6][7]

References[edit]

  1. ^ a b "Travoprost ophthalmic Use During Pregnancy". Drugs.com. 8 October 2019. Retrieved 16 May 2020.
  2. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 9 September 2020.
  3. ^ a b c d e f g "Travoprost Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 26 March 2019.
  4. ^ a b c d e f British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1152. ISBN 9780857113382.
  5. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  6. ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  7. ^ "Travoprost - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
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