Interleukin 11 receptor alpha subunit

IL11RA
Identifiers
Aliases	IL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha
External IDs	OMIM: 600939; MGI: 109123; HomoloGene: 88705; GeneCards: IL11RA; OMA:IL11RA - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 34,652,162 bp End 34,661,902 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 A5|4 22.73 cM Start 42,656,001 bp End 42,665,763 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart Descending thoracic aorta right auricle ascending aorta granulocyte muscle layer of sigmoid colon right coronary artery right hemisphere of cerebellum left lobe of thyroid gland left uterine tube Top expressed in granular layer of epidermis spermatocyte dental follicle blood vessel third ventricle cartilage tissue tracheobronchial tree bronchus tongue dermis More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine receptor activity transmembrane signaling receptor activity signal transducer activity interleukin-11 receptor activity cytokine binding interleukin-11 binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane receptor complex Biological process head development embryo implantation developmental process cytokine-mediated signaling pathway positive regulation of cell population proliferation interleukin-11-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3590 16158 Ensembl ENSG00000137070 ENSMUSG00000078735 UniProt Q14626 P70225 RefSeq (mRNA) NM_001142784 NM_004512 NM_147162 NM_010550 RefSeq (protein) NP_001136256 NP_001092818 NP_001365603 Location (UCSC) Chr 9: 34.65 – 34.66 Mb Chr 4: 42.66 – 42.67 Mb PubMed search
Wikidata
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Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.

Further reading

• Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11". Blood. 86 (7): 2534–40. doi:10.1182/blood.V86.7.2534.bloodjournal8672534 (inactive 2024-05-13). PMID 7670098.{{cite journal}}: CS1 maint: DOI inactive as of May 2024 (link)
• Chérel M, Sorel M, Apiou F, et al. (1996). "The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping". Genomics. 32 (1): 49–53. doi:10.1006/geno.1996.0075. PMID 8786120.
• Van Leuven F, Stas L, Hilliker C, et al. (1996). "Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13". Genomics. 31 (1): 65–70. doi:10.1006/geno.1996.0010. PMID 8808281.
• Magrangeas F, Pitiot G, Dubois S, et al. (1998). "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution". J. Biol. Chem. 273 (26): 16005–10. doi:10.1074/jbc.273.26.16005. PMID 9632650.
• Barton VA, Hudson KR, Heath JK (1999). "Identification of three distinct receptor binding sites of murine interleukin-11". J. Biol. Chem. 274 (9): 5755–61. doi:10.1074/jbc.274.9.5755. PMID 10026196.
• Tacken I, Dahmen H, Boisteau O, et al. (1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis". Eur. J. Biochem. 265 (2): 645–55. doi:10.1046/j.1432-1327.1999.00755.x. PMID 10504396.
• Campbell CL, Jiang Z, Savarese DM, Savarese TM (2001). "Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma". Am. J. Pathol. 158 (1): 25–32. doi:10.1016/S0002-9440(10)63940-5. PMC 1850253. PMID 11141475.
• Cork BA, Tuckerman EM, Li TC, Laird SM (2003). "Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro". Mol. Hum. Reprod. 8 (9): 841–8. doi:10.1093/molehr/8.9.841. PMID 12200462.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Karpovich N, Chobotova K, Carver J, et al. (2003). "Expression and function of interleukin-11 and its receptor alpha in the human endometrium". Mol. Hum. Reprod. 9 (2): 75–80. doi:10.1093/molehr/gag012. PMC 1626582. PMID 12569176.
• Kiessling S, Muller-Newen G, Leeb SN, et al. (2004). "Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells". J. Biol. Chem. 279 (11): 10304–15. doi:10.1074/jbc.M312757200. PMID 14701802.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zurita AJ, Troncoso P, Cardó-Vila M, et al. (2004). "Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer". Cancer Res. 64 (2): 435–9. doi:10.1158/0008-5472.CAN-03-2675. PMID 14744752.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tsimanis A, Shtalrid M, Shvidel L, et al. (2005). "Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma". Leuk. Lymphoma. 45 (11): 2315–9. doi:10.1080/10428190412331283161. PMID 15512823. S2CID 27011485.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Karube K, Ohshima K, Suzumiya J, et al. (2006). "Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha". Ann. Oncol. 17 (1): 110–6. doi:10.1093/annonc/mdj064. PMID 16291580.
• Hanavadi S, Martin TA, Watkins G, et al. (2006). "Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer". Ann. Surg. Oncol. 13 (6): 802–8. doi:10.1245/ASO.2006.05.028. PMID 16614887. S2CID 5693500.
• Yoshizaki A, Nakayama T, Yamazumi K, et al. (2006). "Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells". Int. J. Oncol. 29 (4): 869–76. doi:10.3892/ijo.29.4.869. PMID 16964382.
• Nakayama T, Yoshizaki A, Izumida S, et al. (2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells". Int. J. Oncol. 30 (4): 825–33. doi:10.3892/ijo.30.4.825. PMID 17332920.